DNSP-11 10mg

96.00€

Availability: 49 in stock

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DNSP-11 10 mg research-grade lyophilized D-peptide powder supplied in a glass vial. DNSP-11 is a synthetic D-amino acid peptide designed as an antagonist of the Nogo-66 Receptor 1 (NgR1), a receptor implicated in myelin-associated inhibition of axonal regeneration in central nervous system research models.

Research Use Only: All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use.

Purity

High-purity research grade

Form

Lyophilized D-peptide powder

Content

10 mg DNSP-11 per vial

Packaging

Glass vial with sterile closure

Storage

Store lyophilized at 2–8 °C (desiccated, protect from light)

Molecular formula

C₉₃H₁₅₃N₃₁O₂₂

Molecular weight

~2057.4 g·mol⁻¹

Sequence (D-amino acids)

Ac-[dNle]-[dGlu]-[dHis]-[dHis]-[dGln]-[dLys]-[dLeu]-[dArg]-[dPhe]-[dIle]-[dGlu]-[dDpr]-[dLys]-[dGly]-[dArg]-NH₂

CAS number

To be confirmed

Research Overview

DNSP-11 is a synthetic D-peptide designed to antagonize the Nogo-66 Receptor 1 (NgR1), a neuronal receptor that binds myelin-associated inhibitors such as Nogo-A, MAG and OMgp in central nervous system models. Engagement of NgR1 is associated with reduced axonal growth and regeneration after injury. In in vitro and in vivo laboratory systems, DSNP-11 is used as a tool compound to explore how blocking NgR1 can modulate neurite outgrowth, synaptic plasticity and recovery-related processes in models of CNS damage and repair.

Primary Research Areas

Nogo-66 Receptor (NgR1) antagonism: used in studies focused on disrupting NgR1 signaling initiated by myelin-associated inhibitors, to clarify receptor-dependent checkpoints that restrict axonal growth in central nervous system research models.
Axonal regeneration and neurite outgrowth: applied in neuron culture systems and organotypic preparations to investigate axonal extension, branching and growth cone dynamics when NgR1-mediated inhibition is experimentally reduced or blocked.
Synaptic plasticity and connectivity: incorporated into experimental designs examining how modulation of NgR1 affects synapse formation, spine morphology and plasticity markers in CNS circuits subjected to injury- or experience-dependent remodeling paradigms.
Spinal cord injury and stroke models: used as a tool compound in preclinical models of spinal cord injury, ischemic stroke and related CNS insults to study structural and functional recovery endpoints in the presence of NgR1 antagonism under controlled laboratory conditions.
Overcoming myelin-associated inhibition: evaluated in combination with other experimental strategies (e.g. growth factor delivery, rehabilitation paradigms) to explore synergistic approaches for overcoming myelin-associated growth inhibition in CNS repair research.

Reconstitution

Recommended solvent — Bacteriostatic water

For diluting lyophilized peptide powders, use a sterile and suitable research solvent such as bacteriostatic water (BAC), which may help support handling stability and reduce contamination risk.

For convenient laboratory use, see Bacteriostatic Water – 10 ml.

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Why Limitless Biochem?

Limitless BioChem is a trusted supplier of research compounds. Our products meet strict quality standards and are compliant with EU requirements. We focus on the safe and reliable supply of peptides and pure compounds intended exclusively for research or collector purposes.

This product is not intended for human or veterinary use. It is for collection or research purposes only. It cannot be used as food, dietary supplement or medicine! The information provided in the text on this page is for educational purposes only and does not constitute medical or other advice.